Anna Pagotto, PhD
Anna is a Senior Health Outcomes Researcher with extensive experience in drug discovery, evidence synthesis and scientific literature reviews. Before joining Symmetron, Anna spent several years working as a Scientist at Innate Pharma (Marseille, France) where she led research projects in the Target Discovery and Drug Discovery Departments focused on cancer immunotherapy. Her work involved evaluating new immune checkpoints and tumour antigens for drug development by conducting literature, patent, and clinical trial reviews.
Anna has a strong academic background. In 2012 she obtained a PhD in Clinical Medicine from the University of Oxford. Her research as a PhD student concerned the Cancer/Testis (CT) antigens, a family of tumour-associated antigens that represent ideal targets for cancer immunotherapy. After her PhD she was awarded a Marie Curie post-doctoral fellowship, co-funded by the European Union and the University of Padua. As a Marie-Curie Fellow she studied cancer stem cells and how they can be targeted for therapeutic purposes.
Mazzoldi EL, Pavan S, Pilotto G, Leone K, Pagotto A, Frezzini S, Nicoletto MO, Amadori A, Pastò A. A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer. Cell Death Dis. 2019;10(412).
Pagotto A, Pilotto G, Mazzoldi EL, Nicoletto MO, Frezzini S, Pastò A, Amadori A. Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells. Cell Death Dis. 2017;8(7):e2943.
Pastò A, Pagotto A, Pilotto G, De Paoli A, De Salvo GL, Baldoni A, Nicoletto MO, Ricci F, Damia G, Bellio C, Indraccolo S, Amadori A. Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells. Oncotarget. 2017;8(4):6433-6445.
Pagotto A, Caballero OL, Devalle S, Simpson AJG, Lu X, Christianson JC. Centrosomal localisation of the Cancer/Testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells. PLoS One. 2013;8(12):e83212.
Tordella L, Koch S, Salter V, Pagotto A, Doondeea J, et al. ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci USA. 2013;110(44):17969-74.
Notari M, Hu Y, Koch S, Lu M, Ratnayaka I, Zhong S, Baer C, Pagotto A, Goldin R, Salter V, et al. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci USA. 2011;108(40):16645-16650.
Caballero OL, Zhao Q, Rimoldi D, Stevenson BJ, Svobodova S, Devalle S, Rohrig UF, Pagotto A, Michielin O, Speiser D, et al. Frequent MAGE mutations in human melanoma. PLoS One 2010;5(9).