Bryony Langford, MSc

Bryony has conducted a large number of meta-analyses, network meta-analyses and population-adjusted indirect comparisons to inform HTA submissions and exploratory research. She has also conducted analyses using real-world evidence, using data ranging from small rare disease registries to large medical databases. She has presented findings at conferences including ISPOR and ISCB.

Prior to working at Symmetron, Bryony spent several years working as a Senior Analyst at Costello Medical where she helped found their statistics team. Bryony also has a strong academic background. She completed a Masters in Computational Biology from the University of Cambridge, working with Cancer Research UK and AstraZeneca on a drug development project. This year she will complete an additional Masters in Statistics from the University of Sheffield with the ultimate goal of becoming a Chartered Statistician.


Langford B, Evans M, Haskins-Coulter T, O’connor M, Cant HEO, Eddowes LA, Edmonds C, Tank A. Systematic literature review and network meta-analysis of sodium-glucoses co-transporter inhibitors vs metformin as add-on to insulin in type 1 diabetes. Diabetes Obes Metab. 2020 Jan;22(1):39-50.

Beale R, Conway P, Cai B, Krauter E, Langford B, Hall A, Eddowes L. Indirect Treatment Comparisons and Network Meta-Analyses of Naldemedine for the Treatment of Opioid-Induced Constipation. Value in Health. 2019 May 1;22:S178.

Buchanan-Hughes AM, Buti M, Hanman K, Langford B, Wright M, Eddowes LA. Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis. Quality of Life Research. 2019 Feb 15;28(2):297-319.

Langford BE, Ridley CJ, Beale RC, Caseby SC, Marsh WJ, Richard L. Focused Ultrasound Thalamotomy and Other Interventions for Medication-Refractory Essential Tremor: An Indirect Comparison of Short-Term Impact on Health-Related Quality of Life. Value in Health. 2018 Oct 1;21(10):1168-75.

Langford B, Besford M, Hall A, Eddowes L, Timmis O, Gallagher JA, Ranganath L. Alkaptonuria Severity Score Index Revisited: Analysing the AKUSSI and Its Subcomponent Features. InJIMD Reports, Volume 41 2018 (pp. 53-62). Springer, Berlin, Heidelberg.

Palaka E, Leonard S, Buchanan‐Hughes A, Bobrowska A, Langford B, Grandy S. Evidence in support of hyperkalaemia management strategies: A systematic literature review. International journal of clinical practice. 2018 Feb;72(2):e13052.

Langford B, Evans M, Haskins-Coulter T, O’Connor M, Eddowes LA, Edmonds C, Tank A. Systematic Literature Review and Network Meta-Analysis of SGLT-2 Inhibitors and Metformin as Add-On to Insulin for the Treatment of Type 1 Diabetes. Value in Health. 2018 Oct 1;21:S121.

Langford BE, Beaver S, Besford M, Castell A, Viik AD, Eddowes LA. How Do Nice Evidence Review Groups Perceive Single Technology Appraisals Presenting Limited Evidence of Comparative Treatment Efficacy?. Value in Health. 2017 Oct 1;20(9):A693-4.

Langford BE, McDonald C, Besford M, Griffiths A, Butt T, Jain M. Exploring Concurrent Validity of The CLN2 Clinical Rating Scale: Comparison To Pedsql Using Mixed Effects Modelling And Data From A Phase 1/2 Single-Arm Trial. Value in Health. 2017 Oct 1;20(9):A560.

Langford B, Wickstead R, Marsh W, Beale RC, Evans JS, Kusel J, Griffiths M. Pharmacological Interventions for Familial Hypercholesterolaemia in Children and Adolescents: An Exploratory Evaluation using Advanced Hierarchical Network Meta-Analysis Techniques. Value in Health. 2016 Nov 1;19(7):A380.


Hall A, Langford B, Besford M, Eddowes L. Getting the balance right: comparing propensity score matching algorithms using real-world data from the US National Immunization Survey. ISCB 2017. Poster. 

Steeves S, Langford B, Hall A. Machine learning methods for systematic literature reviews: automated abstract selection based on study design. ISCB 2017. Podium presentation.