Who we are

Meet the team

Bryony Langford, MPhil MSc

Associate Director in Health Outcomes

Bryony leads the Health Outcomes team at Symmetron.

Bryony has extensive experience in evidence generation across a wide range of projects, from gold-standard systematic literature reviews to inform HTA submissions through to early scoping reviews to identify potential comparators of interest and early evidence development strategies. A statistician by training, Bryony has conducted network meta-analyses, population-adjusted indirect comparisons and advanced survival analyses to inform HTA submissions and exploratory research. She has also conducted analyses using real-world data, ranging from small rare disease registries to large medical databases.

Prior to working at Symmetron, Bryony spent several years working as a Senior Analyst at Costello Medical. Bryony also has a strong academic background. She completed a Masters in Computational Biology from the University of Cambridge, and an additional Masters in Statistics from the University of Sheffield.

Systematic literature review and network meta-analysis of sodium-glucoses co-transporter inhibitors vs metformin as add-on to insulin in type 1 diabetes
Cardiometabolic health
Systematic literature review and network meta-analysis of sodium-glucoses co-transporter inhibitors vs metformin as add-on to insulin in type 1 diabetes
Bryony Langford, MPhil MSc
2020
Indirect Treatment Comparisons and Network Meta-Analyses of Naldemedine for the Treatment of Opioid-Induced Constipation
Cardiometabolic health
Indirect Treatment Comparisons and Network Meta-Analyses of Naldemedine for the Treatment of Opioid-Induced Constipation
Bryony Langford, MPhil MSc
2019
Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis
Arthritis and immunology
Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis
Bryony Langford, MPhil MSc
2019
Focused Ultrasound Thalamotomy and Other Interventions for Medication-Refractory Essential Tremor: An Indirect Comparison of Short-Term Impact on Health-Related Quality of Life
Neurology & mental health
Focused Ultrasound Thalamotomy and Other Interventions for Medication-Refractory Essential Tremor: An Indirect Comparison of Short-Term Impact on Health-Related Quality of Life
Bryony Langford, MPhil MSc
2018
Severity Score Index Revisited: Analysing the AKUSSI and Its Subcomponent Features
Policy and methods
Severity Score Index Revisited: Analysing the AKUSSI and Its Subcomponent Features
Bryony Langford, MPhil MSc
2018
Evidence in support of hyperkalaemia management strategies: A systematic literature review. International journal of clinical practice
Cardiometabolic health
Evidence in support of hyperkalaemia management strategies: A systematic literature review. International journal of clinical practice
Bryony Langford, MPhil MSc
2018
Systematic Literature Review and Network Meta-Analysis of SGLT-2 Inhibitors and Metformin as Add-On to Insulin for the Treatment of Type 1 Diabetes
Cardiometabolic health
Systematic Literature Review and Network Meta-Analysis of SGLT-2 Inhibitors and Metformin as Add-On to Insulin for the Treatment of Type 1 Diabetes
Bryony Langford, MPhil MSc
2018
How Do Nice Evidence Review Groups Perceive Single Technology Appraisals Presenting Limited Evidence of Comparative Treatment Efficacy?
Policy and methods
How Do Nice Evidence Review Groups Perceive Single Technology Appraisals Presenting Limited Evidence of Comparative Treatment Efficacy?
Bryony Langford, MPhil MSc
2017
Exploring Concurrent Validity of The CLN2 Clinical Rating Scale: Comparison To Pedsql Using Mixed Effects Modelling And Data From A Phase 1/2 Single-Arm Trial
Policy and methods
Exploring Concurrent Validity of The CLN2 Clinical Rating Scale: Comparison To Pedsql Using Mixed Effects Modelling And Data From A Phase 1/2 Single-Arm Trial
Bryony Langford, MPhil MSc
2017
Pharmacological Interventions for Familial Hypercholesterolaemia in Children and Adolescents: An Exploratory Evaluation using Advanced Hierarchical Network Meta-Analysis Techniques
Cardiometabolic health
Pharmacological Interventions for Familial Hypercholesterolaemia in Children and Adolescents: An Exploratory Evaluation using Advanced Hierarchical Network Meta-Analysis Techniques
Bryony Langford, MPhil MSc
2016

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Training and workshops
Statistical analysis
Medical writing
Health technology assessment
Health economic modelling
Evidence development